Biological activity of a genetically modified BMP-2 variant with inhibitory activity
نویسندگان
چکیده
منابع مشابه
Biological activity of a genetically modified BMP-2 variant with inhibitory activity
BACKGROUND Alterations of the binding epitopes of bone morphogenetic protein-2 (BMP-2) lead to a modified interaction with the ectodomains of BMP receptors. In the present study the biological effect of a BMP-2 double mutant with antagonistic activity was evaluated in vivo. METHODS Equine-derived collagenous carriers were loaded with recombinant human BMP-2 (rhBMP-2) in a well-known dose to p...
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ژورنال
عنوان ژورنال: Head & Face Medicine
سال: 2009
ISSN: 1746-160X
DOI: 10.1186/1746-160x-5-6